Translational control of recombinant human acetylcholinesterase accumulation in plants
نویسندگان
چکیده
منابع مشابه
Translational control of recombinant human acetylcholinesterase accumulation in plants
BACKGROUND Codon usage differences are known to regulate the levels of gene expression in a species-specific manner, with the primary factors often cited to be mRNA processing and accumulation. We have challenged this conclusion by expressing the human acetylcholinesterase coding sequence in transgenic plants in its native GC-rich sequence and compared to a matched sequence with (dicotyledonous...
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Enzyme therapy for the prevention and treatment of organophosphate poisoning depends on the availability of large amounts of cholinesterases. Transgenic plants are being evaluated for their efficiency and cost-effectiveness as a system for the bioproduction of therapeutically valuable proteins. Here we report production of a recombinant isoform of human acetylcholinesterase in transgenic tomato...
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In many parts of the world, groundwater contains so much arsenic that it builds up in irrigated crops. Linked to cancer and heart disease, this toxic element is particularly worrisome in rice, which absorbs arsenic more readily than other grains and is a staple for billions of people. Countries with the double whammy of arsenic-laced groundwater and heavy rice consumption include Bangladesh, In...
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Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer's disease, senile dementia, ataxia and myasthenia gravis. A potential source of AChE inhibitors is certainly provided by the abundance of plants in nature. This article aims to provide a comprehensive lit...
متن کاملAcetylcholinesterase inhibitory effects of some plants from Rosaceae
Background and objectives: Alzheimer's disease (AD) is an age dependent disorder. AD is associated with decrease of brain acetylcholine level. Nowadays, one of the methods for progression inhibition of AD is using acetylcholinesterase inhibitors. Rosaceae is a large plant family. Different biological effects of some species of this family have been reported. The aim of the present study was to ...
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ژورنال
عنوان ژورنال: BMC Biotechnology
سال: 2007
ISSN: 1472-6750
DOI: 10.1186/1472-6750-7-27